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A jury in San Francisco has ruled that, agricultural chemical giant, Monsanto, should pay a groundskeeper over $280 million in compensation after the individual developed a form of cancer after using the weed-killer – Roundup. It’s a complex case that involves allegations of undermining efforts to evaluate a potential link between the active ingredient glyphosate. Accusations of punitive fines and unproven links between the herbicide and the disease. We explore how science goes about proving cause and effect in cases like this?